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Its complex and heterogeneous etiology implies that a range of inherited and environmental factors are involved

As mitochondrial stress and subsequent dysfunction is a typical outcome following high intracellular 4-HNE load 30 , we quantified mitochondrial 4-HNE load by isolating mitochondria from OLs differentiated for 48h

Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss

In addition to direct effects on ion channels, neurotransmitters may bind to G-protein coupled receptors, thereby eliciting cell-signaling effects that could result in metabolic changes (e.g., alterations in activity of various enzymes) within a postsynaptic cell (14)

P., & Deshpande, J